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Cytogenetics is a branch of genetics,
studying the structure and function of the cell
Cytogenetics analyses the number and structure of human and animal chromosomes. Changes that affect the number or structure of the chromosomes can cause problems with growth, development, and how the body functions.
Structural changes in chromosomes can lead to birth defects, syndromes or even cancer. Chromosomal changes may have no effect on a person's health.
Cytogenetic analyses are commonly performed during pregnancy to determine if there is an indication that the fetus is at risk for common aneuplodies (syndromes caused by having extra or missing chromosomes), syndromes caused by structural abnormalities (like unbalanced translocations or inversions), or to determine if extra or missing genetic material is present.
The diagnosis and treatment of several leukemias and lymphomas, as well as some solid tumors, depends today on cytogenetic analysis of specific chromosomal aberrations that are consistently observed in these particular cancers.
The analysis of chromosomes in human development and disease is accomplished through classical cytogenetic procedures, such as G-banding, combined with advanced molecular techniques such as FISH and genomic microarray analysis (CGH) as well as next generation sequencing (NGS).
|  | Little Dipper™ Processor for G-Banding Validated protocols for GTG banding are preprogrammed including a centrifugation step to dry the slides and keep them in the dark until further processing. Users may also create custom protocols to meet special conditions for other probes. more |
Products for Karyotyping | Karyotyping is a technique where the chromosomes from one cell are visualized under a microscope to investigate the total number and structure of the chromosomes. Cells are obtained and cultured from an individual and are analysed during metaphase, a stage in cell division when...⇒ chromosomes are condensed. The chromosomes are stained with Giemsa dye, resulting in a banding pattern of light and dark stripes, known as G-banding. The patterns are specific, allowing to identify each chromosome. | | > read all |
Cell Harvester | Automatic metaphase harvesting is a technique that may be applied all common sample types that are cultured for subsequent cytogenetic analysis.
Typically, automatic metaphase harvesting may offer several attractions to a typical cytogenetics laboratory, where the deployment of...⇒ workforce resource is a compromise | > read all
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MultiPrep Genie 205™
Cytogenetic In Situ Culture Harvester
|  MultiPrep Genie is specifically designed for cytogeneticists carrying out in situ coverslip harvesting and offers true 'walk away' robotic harvesting, not only improving productivity and permitting faster turn around times, but freeing time for the technicians to perform skilled...⇒ tasks such as chromosome analysis. In addition, studies have shown that slides prepared using the robotic harvesting show an improved consistency and indeed an overall improvement in quality over manual coverslip harvesting methods. | > read all
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MultiPrep CellSprint™ Automated Cytogenetic Suspension Culture Harvester |  Multiprep CellSprint has been designed in collaboration with leading cytogenetics laboratories as a true walk-away automation solution designed to relieve suspension culture harvesting workload pressures in busy cytogenetics laboratories.The unique robotic pick and place arm...⇒ places one half of the buckets in the centrifuge in order for the system to begin its parallel processing. Sensors are linked to alarms which will alert the user if the centrifuge is out of balance or misloaded. Each bucket has a unique ID on the corresponding loading tray and the corresponding run data is logged which may then be downloaded from the system for audit purposes. | > read all
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MetaSlide Prep |  The MetaPrep system allows the cytogeneticist full control over climate conditions and cell density for reliable and repeatable slide preparations. It accomplishes this by performing the slide dropping in a nested chamber with optimal airflow at the correct temperature and... | > read all
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ProCell Reagents | | The ProCell cytogenetics reagents range is designed to improve culture failure rates, mitotic index, metaphase spreading, banding resolution and overall quality of bone marrow, lymphoma, solid tumour, blood, CVS and Amniocentesis samples for cytogenetic analysis. | | > go to product page |
Products for CGH | Array CGH is a technology that allows detection of chromosome imbalances that are too small to be detected by microscope. Smaller alterations, often called sub microscopic alterations can still disrupt growth and development. These very small changes are called micro deletions...⇒ and micro duplications. Array CGH is also referred to as CGH array, aCGH or simply a microarray. Array CGH compares a patient DNA sample with a control DNA sample and identifies differences between the two sets of DNA. | | > read all |
Array Processing | Starting with DNA or RNA derived from different sources, specialized instruments work together to perform all labeling, hybridization and post-hybridization microarray processing steps; producing consistently high quality arrays ready for scanning. We offer the relevant...⇒ equipment for all major platforms. | > read all
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NoZone Workspaces |  Maintains Ozone Levels Below 5 ppb Typical day time ozone levels found in most laboratories can destroy Cy5 and other fluorescent dyes used with microarray samples. Studies show that ozone levels as low as 20 ppb can negatively effect array data. The NoZone Workspace was...⇒ developed to eliminate nagging concerns of ozone corrupted array data caused during array washing and scanning. | > read all
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Microarray Ovens |  Series 700 Microarray Ovens provide heating and bubble-mixing of target/probe solutions within microarray hybridization chambers including those supplied by Affymetrix and Agilent. The Model 777 Microarray Oven provides rotational mixing to 80 RPM for Affymetrix GeneChips, and... | | > go to product page |
Little Dipper Processors for Array Work |  A SciGene Little Dipper Microarray Processor is a programmable, robotic instrument that automates the various post-hybridization processing steps used with microarrays and FISH. The Little Dipper instrument improves data quality by eliminating sample handling and by... | > read all
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| Products for FISH | Fluorescence in situ hybridization (FISH) detects the presence, copy numbers and/or location of a DNA sequence within a set of metaphase chromosomes or an interphase nucleus. It is an important molecular cytogenetic technique widely used in diagnosing various genetic disorders...⇒ and/or to further confirm chromosomal abnormalities found by other assays such as karyotyping and array-based comparative genomic hybridization (aCGH).FISH, also known as whole chromosome painting, is valuable in defining rearrangements among different chromosomes and the origin of ring and marker chromosomes that are not clearly deciphered by karyotype analysis. | | > read all |
Hybridization Incubators | | | > go to product page |
CytoBrite Duo Slide Incubation System |  Dual temperature slide heating instrument with superior temperature control for FISH/ISH applications. Two independently controlled heat blocks each hold a removable 6-slide tray. Trays reduce handling from assay setup through hybridization and can be moved between heat blocks...⇒ or transferred to a 60-slide capacity | > read all
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CytoBrite Slide Incubation System |  Programmable system with superior temperature control for performing FISH/ISH hybridization protocols on 1 to 12 slides. Uses rapid Peltier heating and cooling to process FFPE, bone marrow, cell lines and other samples with FISH probes from Abbott, Agilent, Cymogen and Cytocell....⇒ Accurately detects slide temperatures using SlideSense technology for more reproducible results. | > read all
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CytoBrite Slide Oven |  High capacity convection oven with superior temperature control for performing extended or overnight probe denaturation of up to 60 FISH/ISH slides. Slides are uniformly heated to &pusmn; 0.5°C from set point. Up to ten 6-slide trays are easily loaded into five sliding...⇒ drawers. Requires the use of CytoBond Removable Coverslip Sealant to temporarily seal coverslips to slides, providing an evaporative seal over prolonged incubations and high temperatures without humidification. | > read all
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FISH Probes and Reagents | We provide a comprehensive menu of Agilent's Sure FISH probes and reagents for rapid identification of a wide range of chromosomal aberrations across the genome As an Agilent Sales Agency we can provide a completet range of probes and reagents to our customers. In areas we are...⇒ not serving as an Agilent Sales Agency we will make contact to the college serving your area. | > read all
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Automatic Staining and Washing | A SciGene Little Dipper Microarray Processor is a programmable, robotic instrument that automates the various hybridization processing steps used with FISH and G-Banding samples. The Little Dipper instrument improves data quality by eliminating sample handling and by controlling...⇒ wash buffer/reagent temperatures and times, agitation rates and centrifuge/drying conditions. Each system arrives configured for your platform and programmed with recommended protocols. | > read all
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Little Dipper for G-Banding |  The SciGene Little Dipper Processor for GTG Banding provides precisely controlled automation staining processing steps used with GTG banding of chromosomes on slides. The robotic system controls staining, wash, agitation, time and buffer temperatures for processing batches of up...⇒ to 24 slides following optimized protocols. The system eliminates messy jars, waterbaths and staining dishes used in manual methods, freeing up valuable technician time. | > read all
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Little Dipper for FISH | The SciGene Little Dipper Processor for FISH automates slide processing for FISH analysis. The robotic system controls staining, wash, agitation, time and buffer temperatures for processing batches of up to 24 slides following optimized protocols. The system eliminates messy...⇒ jars, water baths and staining dishes used in manual methods, freeing up valuable technician time. | > read all
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